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首頁>>免疫學>>一抗>>膠質源性連接蛋白抗體
膠質源性連接蛋白抗體
  • 產品貨號:
    BN41411R
  • 中文名稱:
    膠質源性連接蛋白抗體
  • 英文名稱:
    Rabbit anti-GDN Polyclonal antibody
  • 品牌:
    Biorigin
  • 貨號

    產品規(guī)格

    售價

    備注

  • BN41411R-100ul

    100ul

    ¥2360.00

    交叉反應:Human,Mouse,Rat(predicted:Dog,Pig,Cow,Rabbit) 推薦應用:WB,IHC-P,IHC-F,IF,ELISA

  • BN41411R-200ul

    200ul

    ¥3490.00

    交叉反應:Human,Mouse,Rat(predicted:Dog,Pig,Cow,Rabbit) 推薦應用:WB,IHC-P,IHC-F,IF,ELISA

產品描述

英文名稱GDN
中文名稱膠質源性連接蛋白抗體
別    名Glia derived nexin; Protease inhibitor 7; GDN; GDN_HUMAN; Glia-derived nexin; P17 antibody Peptidase inhibitor 7; Pi-7; Plasminogen activator inhibitor type 1, member 2; PN-1; PN1; PNI; Protease nexin 1; Protease nexin I; Serpin E2; Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; SERPINE 2; Serpine2.  
研究領域細胞生物  神經(jīng)生物學  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Mouse, Rat,  (predicted: Dog, Pig, Cow, Rabbit, )
產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 (石蠟切片需做抗原修復)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量42kDa
細胞定位細胞外基質 分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human GDN/SERPINE2:301-398/398 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產品介紹The serine protease inhibitors (serpins) compose a superfamily of proteins with a diverse set of functions, including the control of blood coagulation, complement activation, programmed cell death and development. Serpins are secreted glycoproteins that contain a stretch of peptide that mimics a true substrate for a corresponding serine protease. Protease nexin-1 (PN-1) is a serpin that inactivates several proteases, including thrombin, urokinase, plasminogen activators (PA) and plasmin. It is involved in tissue remodeling, cellular invasiveness, matrix degradation and tumor growth. PN-1 expression is abundant in the nervous system, where it inhibits thrombin, thereby playing a role in neural injury and repair processes. An imbalance between PN-1 and thrombin may be a contributing factor in the pathology of Alzheimer’s disease.

Function:
Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin.

Subcellular Location:
Secreted, extracellular space.

Similarity:
Belongs to the serpin family.

SWISS:
P07093

Gene ID:
5270

Database links:

Entrez Gene: 5270 Human

Entrez Gene: 20720 Mouse

Entrez Gene: 29366 Rat

Omim: 177010 Human

SwissProt: P07093 Human

SwissProt: Q07235 Mouse

SwissProt: P07092 Rat

Unigene: 38449 Human

Unigene: 708453 Human

Unigene: 3093 Mouse

Unigene: 2271 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.












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