亚州视频一区二区三区,美乳人妻三级,亚洲色丝袜脚交,潮喷水Xxxxxx

最近搜索:細(xì)胞培養(yǎng) 微生物學(xué) 分子生物 生物化學(xué)
首頁(yè)>>免疫學(xué)>>一抗>>RNA結(jié)合蛋白LIN28抗體
RNA結(jié)合蛋白LIN28抗體
  • 產(chǎn)品貨號(hào):
    BN41327R
  • 中文名稱:
    RNA結(jié)合蛋白LIN28抗體
  • 英文名稱:
    Rabbit anti-Lin28 Polyclonal antibody
  • 品牌:
    Biorigin
  • 貨號(hào)

    產(chǎn)品規(guī)格

    售價(jià)

    備注

  • BN41327R-100ul

    100ul

    ¥2360.00

    交叉反應(yīng):Rat,Mouse(predicted:Sheep,Rabbit,Horse,Cow,Pig,Human) 推薦應(yīng)用:WB,IHC-P,IHC-F,IF,ELISA

  • BN41327R-200ul

    200ul

    ¥3490.00

    交叉反應(yīng):Rat,Mouse(predicted:Sheep,Rabbit,Horse,Cow,Pig,Human) 推薦應(yīng)用:WB,IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱Lin28
中文名稱RNA結(jié)合蛋白LIN28抗體
別    名Lin 28; Lin28A; Lin 28 homolog (C. elegans); Lin 28 homolog A; Lin 28 homolog; Lin-28;y Lin-28 homolog (C. elegans); Lin-28 homolog A; Lin-28A; Lin28; Lin28a; LN28A_HUMAN; Protein lin-28 homolog A; RNA binding protein lin 28; RNA binding protein lin-28; Tex17; ZCCHC1; Zinc finger CCHC domain containing 1; Zinc finger CCHC domain containing protein 1; Zinc finger CCHC domain-containing protein 1; AL024421; CSDD1.  
研究領(lǐng)域細(xì)胞生物  免疫學(xué)  發(fā)育生物學(xué)  神經(jīng)生物學(xué)  干細(xì)胞  表觀遺傳學(xué)  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat,  (predicted: Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 (石蠟切片需做抗原修復(fù))
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量29kDa
細(xì)胞定位細(xì)胞核 細(xì)胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Lin28:75-180/209 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹LIN-28 is a highly conserved, RNA-binding, cytoplasmic protein. It consists of a cold shock domain and retroviral-type (CCHC) zinc finger motifs that were first identified in Caenorhabditis elegans. LIN-28 controls the timing of events during embryonic development and is readily expressed in embryos, embryonic stem cells and embryonal carcinoma cells. The presence of LIN-28 persists in some adult tissues including cardiac and skeletal muscle. In differentiating myoblasts, LIN-28 increases protein synthesis efficiency and binds to the growth and differentiation factor IGF-II.

Function:
Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression (By similarity). Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells. In contrast, LIN28A down-regulation in neural stem cells by miR-125, allows the processing of pre-let-7. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation.

Subunit:
Monomer. During skeletal muscle differentiation, associated with translation initiation complexes in the polysomal compartment. Directly interacts with EIF3S2. Interaction with NCL is RNA-dependent (By similarity). Interacts with ZCCHC11/TUT4.

Subcellular Location:
Cytoplasm. Nucleus > nucleolus. Nucleolar localization observed in 10-15% of the nuclei in differentiated myotubes (By similarity). Shuttles between the cytoplasm and the nucleus. Localizes to cytoplasmic processing bodies and stress granules.

Tissue Specificity:
Expressed in embryonic stem cells (ES cells), placenta and testis.

Similarity:
Belongs to the lin-28 family.
Contains 2 CCHC-type zinc fingers.
Contains 1 CSD (cold-shock) domain.

SWISS:
Q9H9Z2

Gene ID:
79727

Database links:

Entrez Gene: 79727 Human

Entrez Gene: 83557 Mouse

Entrez Gene: 500562 Rat

Omim: 611043 Human

SwissProt: Q9H9Z2 Human

SwissProt: Q8K3Y3 Mouse

Unigene: 86154 Human

Unigene: 302567 Mouse

Unigene: 147538 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.




















image.png

image.png

image.png

image.png

五十路目拍AV| 欧洲国产av| 久久网大香蕉| 黄片欧美小视频| 欧美日韩在线一区麻豆| 黑人精品XXⅩ一区二区三区| 亚洲欧洲日韩久久| 大香煮伊区一二三四区2021自贡| 1a亚洲无码一区| 野外激情啪啪少妇| 欧美性感网站免费观看| 国产老太太尿尿一区二区三区| 极品女老师天堂网| 久久99高潮视频| 日本三级久久一区| 麻豆AV裸聊| 自拍一曲青青草超碰| 国产91字幕| 欧美人妻精品一区二区三区三| 国产麻豆激情在线三级片百度| 91制服丝袜第一页| 女网站a区一二亚洲| 欧美、日韩、国产高清精品在线观看| 国产毛片毛片| 久久久无码91人妻一区二区三区 | 69久久久久久久久久| 美腿丝袜亚洲一区二区| 黄色资源网站在线观| 欧美日韩视频在线网站| 2020无码毛片在线观看| 国产日本欧美综合| 日韩精品一三区| 日韩少妇伺候人妻电影| 艹B 视频在线观看| 麻豆久久亚洲精品网址| 有人操逼视频| 成人国产在线一区二区三区| 最近最新无码a√| 大香蕉久久精彩视频| 香蕉小黄片| 色色老二色色综合网|