亚州视频一区二区三区,美乳人妻三级,亚洲色丝袜脚交,潮喷水Xxxxxx

最近搜索:細(xì)胞培養(yǎng) 微生物學(xué) 分子生物 生物化學(xué)
首頁(yè)>>免疫學(xué)>>一抗>>RNA結(jié)合蛋白LIN28抗體
RNA結(jié)合蛋白LIN28抗體
  • 產(chǎn)品貨號(hào):
    BN41327R
  • 中文名稱:
    RNA結(jié)合蛋白LIN28抗體
  • 英文名稱:
    Rabbit anti-Lin28 Polyclonal antibody
  • 品牌:
    Biorigin
  • 貨號(hào)

    產(chǎn)品規(guī)格

    售價(jià)

    備注

  • BN41327R-100ul

    100ul

    ¥2360.00

    交叉反應(yīng):Rat,Mouse(predicted:Sheep,Rabbit,Horse,Cow,Pig,Human) 推薦應(yīng)用:WB,IHC-P,IHC-F,IF,ELISA

  • BN41327R-200ul

    200ul

    ¥3490.00

    交叉反應(yīng):Rat,Mouse(predicted:Sheep,Rabbit,Horse,Cow,Pig,Human) 推薦應(yīng)用:WB,IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱Lin28
中文名稱RNA結(jié)合蛋白LIN28抗體
別    名Lin 28; Lin28A; Lin 28 homolog (C. elegans); Lin 28 homolog A; Lin 28 homolog; Lin-28;y Lin-28 homolog (C. elegans); Lin-28 homolog A; Lin-28A; Lin28; Lin28a; LN28A_HUMAN; Protein lin-28 homolog A; RNA binding protein lin 28; RNA binding protein lin-28; Tex17; ZCCHC1; Zinc finger CCHC domain containing 1; Zinc finger CCHC domain containing protein 1; Zinc finger CCHC domain-containing protein 1; AL024421; CSDD1.  
研究領(lǐng)域細(xì)胞生物  免疫學(xué)  發(fā)育生物學(xué)  神經(jīng)生物學(xué)  干細(xì)胞  表觀遺傳學(xué)  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat,  (predicted: Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 (石蠟切片需做抗原修復(fù))
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量29kDa
細(xì)胞定位細(xì)胞核 細(xì)胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Lin28:75-180/209 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹LIN-28 is a highly conserved, RNA-binding, cytoplasmic protein. It consists of a cold shock domain and retroviral-type (CCHC) zinc finger motifs that were first identified in Caenorhabditis elegans. LIN-28 controls the timing of events during embryonic development and is readily expressed in embryos, embryonic stem cells and embryonal carcinoma cells. The presence of LIN-28 persists in some adult tissues including cardiac and skeletal muscle. In differentiating myoblasts, LIN-28 increases protein synthesis efficiency and binds to the growth and differentiation factor IGF-II.

Function:
Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression (By similarity). Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells. In contrast, LIN28A down-regulation in neural stem cells by miR-125, allows the processing of pre-let-7. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation.

Subunit:
Monomer. During skeletal muscle differentiation, associated with translation initiation complexes in the polysomal compartment. Directly interacts with EIF3S2. Interaction with NCL is RNA-dependent (By similarity). Interacts with ZCCHC11/TUT4.

Subcellular Location:
Cytoplasm. Nucleus > nucleolus. Nucleolar localization observed in 10-15% of the nuclei in differentiated myotubes (By similarity). Shuttles between the cytoplasm and the nucleus. Localizes to cytoplasmic processing bodies and stress granules.

Tissue Specificity:
Expressed in embryonic stem cells (ES cells), placenta and testis.

Similarity:
Belongs to the lin-28 family.
Contains 2 CCHC-type zinc fingers.
Contains 1 CSD (cold-shock) domain.

SWISS:
Q9H9Z2

Gene ID:
79727

Database links:

Entrez Gene: 79727 Human

Entrez Gene: 83557 Mouse

Entrez Gene: 500562 Rat

Omim: 611043 Human

SwissProt: Q9H9Z2 Human

SwissProt: Q8K3Y3 Mouse

Unigene: 86154 Human

Unigene: 302567 Mouse

Unigene: 147538 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.




















image.png

image.png

image.png

image.png

欧美精品一区二区日韩系列| 国产AV大鸡巴操的舒服| 国产区精品一区| 麻豆国产AV久久| 色插插AV网站| 亚洲欧美人成综合VR| 三级黄在线免费| 国产后入中出大屁股骚逼| 成人av图片专区| 久久黄'色片| 国产欧美后入| 欧美一区二区,精品熟女| 超碰美女福利| 国产老女人喷液抽搐高潮视频| 亚洲天堂欧洲无码| 伊人久我综合| 亚洲AV美日韩AV丝袜美腿护士| 欧美亚洲综合国产视频| 凹凸精品熟女也国产在线| 免费色污黄在线观看| 97超碰久热69熟妇| 五十路人妻AV系列| 人人人人澡人人澡人人澡| 欧美日韩国产综合第一页| 国内外在线激情视频| 日韩在线双飞女主播| 大吉吧插视频| 色狠狠天天综合网| 强美女网站| 人妻素人精品一区| 国产福利 精品一区| 操肉丝尿尿久久久| 国产美女高潮在线观看| 精品亚州视频网站| 精品亚洲日韩电影网| 中文 熟女 人妻 视频| 日本麻豆骚逼国产网站| 天天干天天射天天搞| 天天色天天老熟妇| 日韩欧美黄色中文| 欧美中文无码网址|