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產(chǎn)品規(guī)格
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BN41249R-100ul
100ul
￥2360.00
交叉反應(yīng)：Mouse(predicted:Human) 推薦應(yīng)用：WB,ELISA
BN41249R-200ul
200ul
￥3490.00
交叉反應(yīng)：Mouse(predicted:Human) 推薦應(yīng)用：WB,ELISA
產(chǎn)品描述
| 英文名稱 | LILRB2 |
| 中文名稱 | 細胞表面免疫球蛋白樣轉(zhuǎn)錄因子4抗體 |
| 別 名 | CD85D; CD85 antigen-like family member D; CD85d; CD85d antigen; ILT 4; ILT-4; ILT4; Immunoglobulin like transcript 4; Immunoglobulin-like transcript 4; Leukocyte immunoglobulin like receptor 2; Leukocyte immunoglobulin like receptor subfamily B member 2; Leukocyte immunoglobulin-like receptor 2; Leukocyte immunoglobulin-like receptor subfamily B member 2; Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2; LILRA6; LILRB2; LIR 2; LIR-2; LIR2; LIRb; LIRB2_HUMAN; MIR 10; MIR-10; MIR10; Monocyte/macrophage immunoglobulin like receptor 10; Monocyte/macrophage immunoglobulin-like receptor 10. |
| 研究領(lǐng)域 | 細胞生物 細胞膜受體 細胞表面分子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse, (predicted: Human, ) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000 ELISA=1:5000-10000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 65kDa |
| 細胞定位 | 細胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human LILRB2:1-100/598 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | Leukocyte immunoglobulin-like receptors (LIRs) are members of the immunoglobulin superfamily of glycoproteins and are predominantly expressed by monocytes, B cells, dendritic cells, natural killer (NK) cells, peripheral blood leukocytes and tissues such as placenta, lung and liver. These receptors all contain a cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM), have an inhibitory function and are type I membrane proteins. When they bind to MHC (or other ligands) and ITIM is tyrosine phosphorylated, protein-tyrosine phosphatases are recruited and an inhibitory signal cascade triggered. ILT-4, also designated LIR-2, MIR-10 or CD85D antigen, competes with CD8A for binding to class I MHC antigens. Function: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. Subcellular Location: Membrane. Tissue Specificity: Expressed on monocytes and B-cells, and at lower levels on dendritic cells. Detected at low levels in natural killer (NK) cells. Post-translational modifications: Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6. Similarity: Contains 4 Ig-like C2-type (immunoglobulin-like) domains. SWISS: Q8N423 Gene ID: 10288 Database links: Entrez Gene: 10288 Human Omim: 604815 Human SwissProt: Q8N423 Human Unigene: 655652 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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