亚州视频一区二区三区,美乳人妻三级,亚洲色丝袜脚交,潮喷水Xxxxxx

最近搜索:細胞培養(yǎng) 微生物學 分子生物 生物化學
首頁>>免疫學>>一抗>>磷酸化絲裂原活化蛋白激酶1抗體
磷酸化絲裂原活化蛋白激酶1抗體
  • 產品貨號:
    BN41092R
  • 中文名稱:
    磷酸化絲裂原活化蛋白激酶1抗體
  • 英文名稱:
    Rabbit anti-phospho-MEK1 (Thr386) Polyclonal antibody
  • 品牌:
    Biorigin
  • 貨號

    產品規(guī)格

    售價

    備注

  • BN41092R-100ul

    100ul

    ¥2470.00

    交叉反應:Human,Mouse,Rat(predicted:Chicken,Pig,Horse) 推薦應用:WB,IHC-P,IHC-F,IF,ELISA

產品描述

英文名稱phospho-MEK1 (Thr386)
中文名稱磷酸化絲裂原活化蛋白激酶1抗體
別    名MEK1 (phospho Thr386); MEK1 (phospho T386); p-MEK1 (Thr386); p-MEK1 (T386); Dual specificity mitogen activated protein kinase kinase 1; ERK activator kinase 1; MAP kinase kinase 1; MAP kinase/Erk kinase 1; MAP/Erk kinase 1; Map2K1; MAPK/ERK kinase 1; MAPKK 1; MAPKK1; MEK 1; MEKK1; Mitogen activated protein kinase kinase 1; MKK 1; MKK1; PRKMK 1; PRKMK1;Protein kinase mitogen activated kinase 1 (MAP kinase kinase 1); Protein kinase mitogen activated kinase 1; Protein kinase mitogen activated, kinase 1; MP2K1_HUMAN.  
產品類型磷酸化抗體 
研究領域腫瘤  免疫學  信號轉導  轉錄調節(jié)因子  激酶和磷酸酶  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Mouse, Rat,  (predicted: Chicken, Pig, Horse, )
產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量43kDa
細胞定位細胞核 細胞漿 細胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated Synthesised phosphopeptide derived from human MEK1 around the phosphorylation site of Thr386:SP(p-T)PT 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產品介紹The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.

Function:
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis.

Subunit:
Found in a complex with at least BRAF, HRAS1, MAP2K1, MAPK3/ERK1 and RGS14 (By similarity). Forms an heterodimer with MAP2K2/MEK2 (By similarity). Forms heterodimers with KSR2 which further dimerize to form tetramers (By similarity). Interacts with ARBB2, LAMTOR3, MAPK1/ERK2, MORG1 and RAF1 (By similarity). Interacts with PPARG and with isoform 1 of VRK2. Interacts with Yersinia yopJ. Interacts with SGK1. Interacts with BIRC6/bruce.

Subcellular Location:
Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle pole body. Cytoplasm. Nucleus. Note=Localizes at centrosomes during prometaphase, midzone during anaphase and midbody during telophase/cytokinesis.

Tissue Specificity:
Widely expressed, with extremely low levels in brain.

Post-translational modifications:
Phosphorylation at Ser-218 and Ser-222 by MAP kinase kinase kinases (RAF or MEKK1) positively regulates kinase activity. Also phosphorylated at Thr-292 by MAPK1/ERK2 and at Ser-298 by PAK. MAPK1/ERK2 phosphorylation of Thr-292 occurs in response to cellular adhesion and leads to inhibition of Ser-298 phosphorylation by PAK.

Similarity:
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
Contains 1 protein kinase domain.

SWISS:
Q02750

Gene ID:
5604

Database links:

Entrez Gene: 5604 Human

Entrez Gene: 26395 Mouse

Entrez Gene: 170851 Rat

Omim: 176872 Human

SwissProt: Q02750 Human

SwissProt: P31938 Mouse

SwissProt: Q01986 Rat

Unigene: 145442 Human

Unigene: 248907 Mouse

Unigene: 5850 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

絲裂原活化蛋白激酶是一組可以被多種細胞外信號即獲得蛋白絲/蘇氨酸激酶,處于胞漿信號傳導通路的終末位置,活化后轉位到核內,作用于核內轉錄因子,調節(jié)基因表達。它主要參與生長因子、激素、細胞因子、應激等各種刺激下細胞的反應、細胞的生長、分化過程。經研究證實,MAPK信號轉導通路存在于大多數(shù)細胞內,在將細胞外刺激信號轉導至細胞及其核內,并引起細胞生物學反應(如細胞增殖、分化、轉化及凋亡等)的過程中具有至關重要的作用。研究表明,MAPK信號轉導通路在細胞內具有生物進化的高度保守性,在低等原核細胞和高等哺乳類細胞內,目前均已發(fā)現(xiàn)存在著多條并行的MAPK信號通路,不同的細胞外刺激可使用不同的MAPK信號通路,通過其相互調控而介導不同的細胞生物學反應。


欧美+麻豆+国产| 亚洲精品日韩综合成人91| 日韩精品 欧美潮吹| 中国超级美女大黑逼操逼视频| 日本久久一区二区免高清| 久久精品一区二区町内会| 公久成人电影| 大香蕉久久成人视频| 香蕉网av| 国产精品 你懂得| 按摩精品在线| 一二区影院| 欧美日韩在线观看视频免费播放 | 色色色综合 一区二区 国产| 天天涩天天综合网| 中文字幕高清视频婷婷| 亚洲成人在线免费中文字幕| 亚洲黄色毛片,一区二区| 俄罗斯老太太卖屄视频| www.欧美色停停| 淫色成人综合网| 中文字幕日韩第一页亚洲母乳| 久久午夜视频福利| 久久综合色色色色色色| 国产夫妻在线视频一区| av免费的com| 日韩有码 在线播放| 黑人大巨屌 抽插| 亚洲国产成人无码AⅤ天堂| 国产福利手机在线| 午夜亚洲激情66| 图片区 亚洲无码| 欧美淫荡熟女| 国产精品日韩欧美一区二区99久久| 大香蕉亚洲一二三四| 亚洲国产成人精品天堂| 亚洲热图一区二区| 久久高清视频日本| 欧美一级一级一区二区三区| 亚洲精品23p熟女在线观看| 日本淫秽视频免费在线观看|