亚州视频一区二区三区,美乳人妻三级,亚洲色丝袜脚交,潮喷水Xxxxxx

最近搜索:細(xì)胞培養(yǎng) 微生物學(xué) 分子生物 生物化學(xué)
首頁>>免疫學(xué)>>一抗>>磷酸化轉(zhuǎn)錄因子E2F-1抗體
磷酸化轉(zhuǎn)錄因子E2F-1抗體
  • 產(chǎn)品貨號:
    BN41072R
  • 中文名稱:
    磷酸化轉(zhuǎn)錄因子E2F-1抗體
  • 英文名稱:
    Rabbit anti-phospho-E2F1 (Ser337) Polyclonal antibody
  • 品牌:
    Biorigin
  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN41072R-100ul

    100ul

    ¥2470.00

    交叉反應(yīng):Human,Mouse(predicted:Horse) 推薦應(yīng)用:WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱phospho-E2F1 (Ser337)
中文名稱磷酸化轉(zhuǎn)錄因子E2F-1抗體
別    名phospho-E2F1(Ser337); p-E2F1 (phospho-Ser337); E2F1 (phospho S337); E2F 1; E2F transcription factor 1; E2F-1; E2f1 E2F transcription factor 1; KIAA4009; mKIAA4009; OTTHUMP00000030661; PBR 3; PBR3; PRB binding protein E2F 1; PRB-binding protein E2F-1; RBAP 1; RBAP-1; RBAP1; RBBP 3; RBBP-3; RBBP3; RBP 3; RBP3; Retinoblastoma associated protein 1; Retinoblastoma binding protein 3; Retinoblastoma-associated protein 1; Retinoblastoma-binding protein 3; Transcription factor E2F1; E2F1_HUMAN.  
產(chǎn)品類型磷酸化抗體 
研究領(lǐng)域腫瘤  免疫學(xué)  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Mouse,  (predicted: Human, Horse, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/Test IF=1:100-500 (石蠟切片需做抗原修復(fù))
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量46kDa
細(xì)胞定位細(xì)胞核 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated Synthesised phosphopeptide derived from human E2F1 around the phosphorylation site of Ser337:PS(p-S)PP 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹E2F's are DNA binding proteins, which associate with negative regulators, such as the retinoblastoma p107 protein, resulting in an altered rate of gene transcription. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. E2F1 is proposed to be involved in several cellular processes that range from tumor suppressor, cell progression and oncogenesis. E2F1 overexpression can also drive cells into apoptosis.

Function:
Transcription activator that binds DNA cooperatively with dp proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F-1 binds preferentially RB1 protein, in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent apoptosis.

Subunit:
Component of the DRTF1/E2F transcription factor complex. Forms heterodimers with DP family members. The E2F-1 complex binds specifically hypophosphorylated retinoblastoma protein RB1. During the cell cycle, RB1 becomes phosphorylated in mid-to-late G1 phase, detaches from the DRTF1/E2F complex, rendering E2F transcriptionally active. Interacts with TRRAP, which probably mediates its interaction with histone acetyltransferase complexes, leading to transcription activation. Binds TOPBP1. Interacts with ARID3A (By similarity). Binds EAPP.

Subcellular Location:
Nucleus.

Post-translational modifications:
Phosphorylated by CDK2 and cyclin A-CDK2 in the S-phase (By similarity).

Similarity:
Belongs to the E2F/DP family.

SWISS:
Q01094

Gene ID:
1869

Database links:

Entrez Gene: 1869 Human

Omim: 189971 Human

SwissProt: Q01094 Human

Unigene: 654393 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

E2F1—屬于調(diào)節(jié)性轉(zhuǎn)錄因子E2F家族。有學(xué)者認(rèn)為:E2F-1既可作為癌基因起作用,又可作為抑癌基因起作用。其不同可能由細(xì)胞中其他生長促進(jìn)或抑制性蛋白質(zhì)水平和(或)活性決定,同時與細(xì)胞所處環(huán)境及器官特異性有關(guān)。在控制細(xì)胞周期和腫瘤抑制基因蛋白的活性方面起關(guān)鍵作用。


日本一区二区草草影院| 大型成人一区二区三区| 一区二区aV中日韩| 91大香蕉伊人亚洲视频| 久久中文乱码一区| 久久久午夜三级片| 黄色分泌物是怎么回事| 亚洲日韩一道本中文字幕无码破解 | 亚洲楿蕉视频| 五月婷婷丁香激情网| 黄性aaav| www.日本妞| 国自产偷拍精品| 中文字幕一区二区三区咪咪| 欧亚一区二区三区久久| 97免费观看视频精品| 人妻紧致后入3| 中文字幕精品一区二区三区电影 | 蜜乳中文字幕精品一区二区| 一区二区激情av| 一二三激情视频| 国产熟女乱精品| 经典一级黄片A区| 色日本在线视频| 欧美激情_第1页_高清免费在线| 成人免费AV| 成人品视频网站| 日本人妻少婦| 美女被日B| 水蜜桃午夜福利| 自拍偷怕二区| 国产视频美女一区| 精品久久狠狠| 欧美影院专区一专区二| 亚洲国产一卡二卡三卡| 国产精区二区三区| 日韩美女色入视频| 狠狠躁久久久| 一区二区 久久| 国产成人综合色自拍大香蕉| 久久精品免费看少妇|