亚州视频一区二区三区,美乳人妻三级,亚洲色丝袜脚交,潮喷水Xxxxxx

最近搜索:細胞培養(yǎng) 微生物學(xué) 分子生物 生物化學(xué)
首頁>>免疫學(xué)>>一抗>>磷酸化CREB轉(zhuǎn)錄共激活因子TORC2抗體
磷酸化CREB轉(zhuǎn)錄共激活因子TORC2抗體
  • 產(chǎn)品貨號:
    BN40913R
  • 中文名稱:
    磷酸化CREB轉(zhuǎn)錄共激活因子TORC2抗體
  • 英文名稱:
    Rabbit anti-Phospho-TORC2 (Ser171) Polyclonal antibody
  • 品牌:
    Biorigin
  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN40913R-100ul

    100ul

    ¥2470.00

    交叉反應(yīng):Human,Mouse(predicted:Rat,Dog,Pig) 推薦應(yīng)用:WB,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱Phospho-TORC2 (Ser171)
中文名稱磷酸化CREB轉(zhuǎn)錄共激活因子TORC2抗體
別    名TORC2 (phospho S171); TORC2 (phospho Ser171); p-TORC2 (Ser171); CREB regulated transcription coactivator 2; CRTC2; RP11-422P24.6; TORC-2; Transducer of CREB protein 2; Transducer of regulated cAMP response element-binding protein; Transducer of regulated cAMP response element-binding protein (CREB) 2; Transducer of regulated cAMP response element-binding protein 2; Transducer of regulated CREB protein 2; CRTC2_HUMAN. 




產(chǎn)品類型磷酸化抗體 
研究領(lǐng)域腫瘤  免疫學(xué)  信號轉(zhuǎn)導(dǎo)  細胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  激酶和磷酸酶  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse,  (predicted: Rat, Dog, Pig, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 Flow-Cyt=1ug/Test 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量73kDa
細胞定位細胞核 細胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated Synthesised phosphopeptide derived from human CREB regulated transcription coactivator 2 around the phosphorylation site of Ser171:TS(p-S)DS 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2010].

Function:
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).

Subunit:
Binds, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1. 'Arg-314' in the bZIP domain of CREB1 is essential for this interaction. Interaction, via its C-terminal, with TAF4, enhances recruitment of TAF4 to CREB1. Interacts with PPP3CA/calcineurin alpha, SIK2 and 14-3-3 proteins, YWHAB and YWHAG. Interaction with the human T-cell leukemia virus type 1 (HTLV-1) Tax protein is essential for optimal transcription activation by Tax. Interaction with RFWD2/COP1 mediates nuclear export and degradation of CRTC2.

Subcellular Location:
Cytoplasm. Nucleus. Note=Translocated from the nucleus to the cytoplasm on interaction of the phosphorylated form with 14-3-3 protein. In response to cAMP levels and glucagon, relocated to the nucleus.

Tissue Specificity:
Most abundantly expressed in the thymus. Present in both B and T-lymphocytes. Highly expressed in HEK293T cells and in insulinomas. High levels also in spleen, ovary, muscle and lung, with highest levels in muscle. Lower levels found in brain, colon, heart, kidney, prostate, small intestine and stomach. Weak expression in liver and pancreas.

Post-translational modifications:
Phosphorylation/dephosphorylation states of Ser-171 are required for regulating transduction of CREB activity. TORCs are inactive when phosphorylated, and active when dephosphorylated at this site. This primary site of phosphorylation, is regulated by cAMP and calcium levels and is dependent on the phosphorylation of SIKs (SIK1 and SIK2) by LKB1. Both insulin and AMPK increase this phosphorylation of CRTC2 while glucagon suppresses it. Phosphorylation at Ser-274 by MARK2 is induced under low glucose conditions and dephosphorylated in response to glucose influx. Phosphorylation at Ser-274 promotes interaction with 14-3-3 proteins and translocation to the cytoplasm.

Similarity:
Belongs to the TORC family.

SWISS:
Q53ET0

Gene ID:
200186

Database links:

Entrez Gene: 200186 Human

Entrez Gene: 74343 Mouse

Entrez Gene: 310615 Rat

Omim: 608972 Human

SwissProt: Q53ET0 Human

SwissProt: Q3U182 Mouse

SwissProt: Q3LRZ1 Rat

Unigene: 406392 Human

Unigene: 35627 Mouse

Unigene: 13599 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CREB轉(zhuǎn)錄共激活因子TORC2又稱葡萄糖關(guān)鍵調(diào)控蛋白TORC-2。


麻豆激情男女激情视频| 日本婷婷中文色色| 97cao超碰| 色综合久久久久| 人人爽人人妻视频| 国产精品122区| 久久精品内射欧美| 欧美日韩视频一区二区视频在线| 亚洲av资源网站在线观看| 销魂美女视频在线观看网站免费日韩 | 日本一二三级在线| 久久之日本| 天堂精品MV一区二区三区| 老熟女激情85| 人妻上一页| 中文字幕日韩黄色影片| 啪啪啪网站一区二区三区| 日韩3级片网站| 亚洲无码大尺度视频| 欧美精品草草草| 亚洲精品成人片| 亚洲无码三级在线观看免费的| 人人干人人爽影院| 另类图片 中文字幕 欧美专区| 欧美3p亚洲区| 丰满人妻一区二区三区四区53| 亚洲天堂av播放| 骚逼社区AV| 国产精品自拍人妻一区二区在线观看 | 呦呦呦呦在线| 天天橾天天人| 欧美图片久久一区二区三区四区五区| 亚州乱码| 成人干天天操天天射| av有码午夜福利| 亚洲 欧美 日韩一区二区| 欧美少妇一区久久久| 妍妍女王调教69一区二区| 欧洲日韩亚洲一区| 日本在线不卡精彩视频| 第四色大香蕉|