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產(chǎn)品規(guī)格
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BN40709R-100ul
100ul
￥2360.00
交叉反應(yīng)：Mouse,Rat(predicted:Human,Dog,Pig,Cow,Horse,Sheep) 推薦應(yīng)用：IHC-P
BN40709R-200ul
200ul
￥3490.00
交叉反應(yīng)：Mouse,Rat(predicted:Human,Dog,Pig,Cow,Horse,Sheep) 推薦應(yīng)用：IHC-P
產(chǎn)品描述
| 英文名稱(chēng) | UBF1 |
| 中文名稱(chēng) | RNA聚合酶I抗體 |
| 別 名 | UBF; NOR 90; Nucleolar transcription factor 1; UBF 1; UBF-1; UBF; UBTF; Autoantigen NOR-90; Upstream-binding factor 1; Upstream binding factor 1; upstream binding transcription factor, RNA polymerase I; UBF1_HUMAN. |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 染色質(zhì)和核信號(hào) 轉(zhuǎn)錄調(diào)節(jié)因子 |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應(yīng) | Mouse, Rat, (predicted: Human, Dog, Pig, Cow, Horse, Sheep, ) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 89kDa |
| 細(xì)胞定位 | 細(xì)胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human UBF1:611-710/764 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | This gene encodes a member of the HMG-box DNA-binding protein family. The encoded protein plays a critical role in ribosomal RNA transcription as a key component of the pre-initiation complex, mediating the recruitment of RNA polymerase I to rDNA promoter regions. The encoded protein may also play important roles in chromatin remodeling and pre-rRNA processing, and its activity is regulated by both phosphorylation and acetylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3, 11 and X and the long arm of chromosome 11. [provided by RefSeq, Aug 2011] Function: Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element. Subcellular Location: Nucleus Post-translational modifications: Phosphorylated and activated by PIK3CA. Similarity: Contains 6 HMG box DNA-binding domains. SWISS: P17480 Gene ID: 7343 Database links: Entrez Gene: 7343 Human Entrez Gene: 21429 Mouse Omim: 600673 Human SwissProt: P17480 Human SwissProt: P25976 Mouse Unigene: 89781 Human Unigene: 2845 Mouse Unigene: 22469 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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