亚州视频一区二区三区,美乳人妻三级,亚洲色丝袜脚交,潮喷水Xxxxxx

最近搜索:細胞培養(yǎng) 微生物學 分子生物 生物化學
首頁>>免疫學>>一抗>>環(huán)腺苷酸應答元件結合蛋白抗體
環(huán)腺苷酸應答元件結合蛋白抗體
  • 產品貨號:
    BN40633R
  • 中文名稱:
    環(huán)腺苷酸應答元件結合蛋白抗體
  • 英文名稱:
    Rabbit anti-CREB-1 Polyclonal antibody
  • 品牌:
    Biorigin
  • 貨號

    產品規(guī)格

    售價

    備注

  • BN40633R-100ul

    100ul

    ¥2360.00

    交叉反應:Human,Mouse,Rat 推薦應用:WB,Flow-Cyt,ELISA

  • BN40633R-200ul

    200ul

    ¥3490.00

    交叉反應:Human,Mouse,Rat 推薦應用:WB,Flow-Cyt,ELISA

產品描述

英文名稱CREB-1
中文名稱環(huán)腺苷酸應答元件結合蛋白抗體
別    名Active transcription factor CREB; cAMP response element binding protein; cAMP responsive element binding protein 1; CREB1; CREB 1; CREB1; MGC9284; Transactivator protein; CREB; CREB1_HUMAN.  


研究領域免疫學  染色質和核信號  信號轉導  轉錄調節(jié)因子  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Mouse, Rat, 
產品應用WB=1:500-2000 ELISA=1:5000-10000 Flow-Cyt=1μg/Test 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量37kDa
細胞定位細胞核 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human CREB-1:51-120/341 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產品介紹Cyclic AMP Response Element Binding protein (CREB) is a basic / leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors. Activation of CREB is dependent upon the phosphorylation of serine 133. Phosphorylation occurs via p44 / 42 MAP kinase and p90RSK and also via p38 MAP kinase and MSK 1. Although CREB will bind DNA independent of its phosphorylation state, only the phosphorylated form is competent as a transcription factor. CREB binding protein (CBP), a transcriptional coactivator that directly interacts with CREB, binds to CREB in the region of serine 133. CREB appears to play an important role in learning and memory. CREB knock out mice show diminished learning ability.

Function:
Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.

Subunit:
Interacts with PPRC1. Binds DNA as a dimer. This dimer is stabilized by magnesium ions. Interacts, through the bZIP domain, with the coactivators TORC1/CRTC1, TORC2/CRTC2 and TORC3/CRTC3. When phosphorylated on Ser-133, binds CREBBP (By similarity). Interacts with CREBL2; regulates CREB1 phosphorylation, stability and transcriptional activity (By similarity). Interacts (phosphorylated form) with TOX3. Interacts with ARRB1. Binds to HIPK2. Interacts with SGK1.

Subcellular Location:
Nucleus.

Post-translational modifications:
Stimulated by phosphorylation. Phosphorylation of both Ser-133 and Ser-142 in the SCN regulates the activity of CREB and participates in circadian rhythm generation. Phosphorylation of Ser-133 allows CREBBP binding (By similarity). CREBL2 positively regulates phosphorylation at Ser-133 thereby stimulating CREB1 transcriptional activity (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylated upon calcium influx by CaMK4 and CaMK2 on Ser-133. CaMK4 is much more potent than CaMK2 in activating CREB. Phosphorylated by CaMK2 on Ser-142. Phosphorylation of Ser-142 blocks CREB-mediated transcription even when Ser-133 is phosphorylated. Phosphorylated by CaMK1 (By similarity). Phosphorylation of Ser-271 by HIPK2 in response to genotoxic stress promotes CREB1 activity, facilitating the recruitment of the coactivator CBP. Phosphorylated at Ser-133 by RPS6KA3, RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli.
Sumoylated with SUMO1. Sumoylation on Lys-304, but not on Lys-285, is required for nuclear localization of this protein. Sumoylation is enhanced under hypoxia, promoting nuclear localization and stabilization.

DISEASE:
Defects in CREB1 may be a cause of angiomatoid fibrous histiocytoma (AFH) [MIM:612160]. A distinct variant of malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a lymph node metastasis. Note=A chromosomal aberration involving CREB1 is found in a patient with angiomatoid fibrous histiocytoma. Translocation t(2;22)(q33;q12) with CREB1 generates a EWSR1/CREB1 fusion gene that is most common genetic abnormality in this tumor type.
Note=A CREB1 mutation has been found in a patient with multiple congenital anomalies consisting of agenesis of the corpus callosum, cerebellar hypoplasia, severe neonatal respiratory distress refractory to surfactant, thymus hypoplasia, and thyroid follicular hypoplasia (PubMed:22267179).

Similarity:
Belongs to the bZIP family.
Contains 1 bZIP domain.
Contains 1 KID (kinase-inducible) domain.

SWISS:
P16220

Gene ID:
1385

Database links:

Entrez Gene: 281713 Cow

Entrez Gene: 1385 Human

Entrez Gene: 12912 Mouse

Entrez Gene: 81646 Rat

Omim: 123810 Human

SwissProt: P27925 Cow

SwissProt: P16220 Human

SwissProt: Q01147 Mouse

SwissProt: P15337 Rat

Unigene: 516646 Human

Unigene: 453295 Mouse

Unigene: 90061 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


環(huán)腺苷酸應答元件結合蛋白(cAMP responsive element binding protein, CREB)是真核細胞轉錄因子,屬于ATF/CREB家族。參與由cAMP或某些病毒蛋白質所誘導基因轉錄的調節(jié)。
ATF/CREB家族相關蛋白


成人免费一区二区三区| 黄片影院免费观看| 午夜日韩精品电影| 香蕉视频一二三四区| 国产三级高清一区二区| 夜夜人人操| 欧美日韩不卡影院| 尹人香蕉综合网| 美女被几把插入| 台湾精品在线视频| 亚洲成人AV福利| 欧美不卡免费视频天天爽| 97csoporn| 天天躁夜夜躁xxx| 日摸夜夜欧美一区二区亚洲国产| 夜夜嗨九色av| 靑青操逼| 熟女国产五十路熟妇| 好吊日视频这里全是精品| 午夜福利视频了| 天天爽天天操天天射| 久久艹吃鸡巴视频| 激情六月婷婷同性恋| 一级黄片欧美日韩| 精品视频,亚洲国产| 五月天色婷婷av无码| 国产精品午夜啪啪啪| 综合一区中色婷婷| 久久久国产欧美网站在线观看| 精品大陆AV| 人妻少妇精品一品级上班了| 国产欧美在现观看一区二区| 日本福利视频网站中文字幕| 人妻捆绑后入| 麻豆一区二区hhh| 维族淫秽视频网站在线播放| av不卡国内在线| 无码二区多人| 国产内射人妻| 黑人的鸡把插入女人视频| 午夜成人AV福利|