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產(chǎn)品規(guī)格
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BN40619R-100ul
100ul
￥2360.00
交叉反應：Human,Mouse,Rat 推薦應用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt
BN40619R-200ul
200ul
￥3490.00
交叉反應：Human,Mouse,Rat 推薦應用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt
產(chǎn)品描述
| 英文名稱 | GPR30 |
| 中文名稱 | G蛋白偶聯(lián)受體30抗體 |
| 別 名 | G Protein Coupled Receptor 30; G-protein coupled receptor 30; G-protein coupled estrogen receptor 1; Membrane estrogen receptor; mER; Chemokine receptor-like 2; IL8-related receptor DRY12; Flow-induced endothelial G-protein coupled receptor 1; FEG-1; Lymphocyte-derived G-protein coupled receptor; LYGPR; GPCR-BR; CEPR; CMKRL2; DRY12; GPER. |
| 研究領(lǐng)域 | 細胞生物 神經(jīng)生物學 信號轉(zhuǎn)導 細胞膜受體 G蛋白偶聯(lián)受體 G蛋白信號 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應 | Human, Mouse, Rat, |
| 產(chǎn)品應用 | WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test ICC=1:100 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 42kDa |
| 細胞定位 | 細胞核 細胞漿 細胞膜 細胞外基質(zhì) |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GPR30:21-120/375 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | G protein-coupled receptors (GPRs, or GPCRs) contain 7 hydrophobic transmembrane domains embedded in hydrophilic intra- and extracellular loops and transduce a variety of hormone, endogenous peptide, and neurotransmitter signals into intracellular effects via G proteins. GRP30 is a member of this family and is an orphan receptor. GPR30 expression has been reported in brain, breast carcinoma, blood, bone marrow, CNS, heart, liver, lung, lymph node, placenta, and spleen. In brain, GPR30 is expressed as a 2.8 kb transcript in basal forebrain, frontal cortex, thalamus, hippocampus, caudate and putamen. However, unlike other known G protein-coupled receptors, GPR30 localizes to the endoplasmic reticulum, where it specifically binds estrogen and estrogen derivatives. Function: Receptor for estrogen. Subcellular Location: Cell membrane. Endoplasmic reticulum membrane. Golgi apparatus membrane. Protein has been detected in the cell membrane, endoplasmic reticulum and Golgi apparatus. It is currently unclear whether this is a cell surface or intracellular receptor. Tissue Specificity: Ubiquitously expressed, but is most abundant in placenta. In brain regions, expressed as a 2.8 kb transcript in basal forebrain, frontal cortex, thalamus, hippocampus, caudate and putamen. Similarity: Belongs to the G-protein coupled receptor 1 family. SWISS: Q99527 Gene ID: 2852 Database links: Entrez Gene: 2852 Human Entrez Gene: 76854 Mouse Omim: 601805 Human SwissProt: Q99527 Human SwissProt: Q8BMP4 Mouse Unigene: 20961 Human Unigene: 389706 Mouse Unigene: 9806 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. GPR30是一種膜性雌激素蛋白受體又稱非基因型雌激素膜性受體GPR30。GPR30受體廣泛表達于海馬、下丘腦、子宮、卵巢、乳腺、骨和心血管等全身多個系統(tǒng)、器官和組織,在細胞內(nèi)主要定位于細胞膜、內(nèi)質(zhì)網(wǎng)、線粒體和高爾基體。 GPER與雌激素結(jié)合, ERK、PI3K/AKT)、 cAMP等第二信使途徑發(fā)揮快速非基因效應,在神經(jīng)系統(tǒng)、生殖系統(tǒng)、運動系統(tǒng)和心血管系統(tǒng)中發(fā)揮重要的生理作用。 |
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